Research articles | Nature (2025)

Strategies for climate-resilient global wind and solar power systems

• Dongsheng Zheng
• Xizhe Yan
• Qiang Zhang

On the effects of fault alignment on slip stability

• Yuri Fialko
• Yoshihiro Kaneko

Reply to: On the effects of fault alignment on slip stability

• Jaeseok Lee
• Victor C. Tsai
• Daniel T. Trugman

Unsupervised pretraining in biological neural networks

During visual learning, neural plasticity is driven by unsupervised learning in mice.

• Lin Zhong
• Scott Baptista
• Marius Pachitariu

Complete computational design of high-efficiency Kemp elimination enzymes

We present a computational approach to the design of high-efficiency enzymes with catalytic parameters comparable to natural enzymes, enabling programming of stable, high-efficiency, new-to-nature Kemp elimination enzymes through minimal experimental effort.

• Dina Listov
• Eva Vos
• Sarel J. Fleishman

Optical nonlinearities in excess of 500 through sublattice reconstruction

A strategy for engineering photon-avalanche nanoparticles is proposed such that they exhibit an unprecedentedly strong nonlinear optical response and their emissions scale by more than 500th power of the pump intensity.

• Jiaye Chen
• Chang Liu
• Xiaogang Liu

Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis

Insights into the dogrose genome and centromeres explain their ability to achieve stable sexual reproduction.

• V. Herklotz
• M. Zhang
• C. M. Ritz

Kupffer cell programming by maternal obesity triggers fatty liver disease

In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

• Hao Huang
• Nora R. Balzer
• Elvira Mass

Allosteric modulation and biased signalling at free fatty acid receptor 2

Structural,pharmacological and computationalstudies reveal how different classes of positive allosteric modulators bind to distinct allosteric sites and use noncanonical mechanisms to activate the free-fatty acid receptor FFA2.

• Xuan Zhang
• Abdul-Akim Guseinov
• Cheng Zhang

Machine-learning design of ductile FeNiCoAlTa alloys with high strength

A new group of multi-principal-element alloys, designed through machine learning and extreme microstructural heterogeneities, achieve high strength (1.8-GPa yield strength) and ductility (25% uniform elongation) at room temperature.

• Yasir Sohail
• Chongle Zhang
• En Ma

Impacts of climate change on global agriculture accounting for adaptation

Analysis of data on six stable crops, capturing two-thirds of global crop calories, allows estimation ofagricultural impacts and the potential of global producer adaptations to reduceoutput losses owing to climate change.

• Andrew Hultgren
• Tamma Carleton
• Jiacan Yuan

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation

Dysregulated CD4 T cells that recognize gut commensal antigens are able to infiltrate the central nervous systems and are re-stimulated by host proteins, resulting in neuroinflammation.

• Zachary White
• Ivan Cabrera
• Teruyuki Sano

Targeting de novo purine biosynthesis for tuberculosis treatment

The validation of inhibitors targetingPurF, a novel drug targetfor tuberculosisdrug discovery, is described.

• Dirk A. Lamprecht
• Richard J. Wall
• Anil Koul

Morphodynamics of human early brain organoid development

Human brain morphodynamics are explored using organoids.

• Akanksha Jain
• Gilles Gut
• Barbara Treutlein

Bioinspired capillaryforce-driven super-adhesive filter

Stable coating of filters with a thin liquid layer enhances adhesion of airborne particulates while maintaining high air permeability, resulting in longer lifetimes and higher efficiency of these filters.

• Junyong Park
• Chan Sik Moon
• Sanghyuk Wooh

Bogong moths use a stellar compass for long-distance navigation at night

Every spring, Bogong moths use the starry night sky as a compass to navigate up to 1,000 km towards their alpine migratory goal.

• David Dreyer
• Andrea Adden
• Eric Warrant

Major expansion in the human niche preceded out of Africa dispersal

Analysis of species distribution models in a pan-African database comprising chronometrically dated archaeological sites over the past 120,000 years shows major expansion in the human niche from 70 ka, driven by adaptation to diverse habitats.

• Emily Y. Hallett
• Michela Leonardi
• Eleanor M. L. Scerri

In vivo mapping of mutagenesis sensitivity of human enhancers

Human enhancers contain a high density of sequence features that are required for their normal in vivo function.

• Michael Kosicki
• Boyang Zhang
• Len A. Pennacchio

Single-cell transcriptomic and chromatin dynamics of the human brainin PTSD

A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.

• Ahyeon Hwang
• Mario Skarica
• Matthew J. Girgenti

Vertically stacked monolithic perovskite colour photodetectors

A colour sensor array based on multilayer monolithically stacked lead halide perovskite thin-film photodetectors achieves higher quantum efficiency and superior colour accuracy compared to conventional filter-based image sensors.

• Sergey Tsarev
• Daria Proniakova
• Maksym V. Kovalenko